Speaker Rt. Hon. Moses Wetang’ula began his political career in 1993 when he was nominated to the 7 th Parliament (1993- 1997). He served for five cumulative terms between 1993 and 2013 as a Member of the National Assembly for Sirisia Constituency, and as Senator for Bungoma County for the period (2013-2022). During his first term as a Nominated Member, he served as a member of the Speaker’s Panel (Temporary Deputy Speaker), the House Business Committee as well as the Committee on Defence & Foreign Relations. He was also an active Member of the CPA Executive Committee. In the 7th Parliament, he led various reforms to the House's rules of procedure and was the Leader of the Kenya delegation to the African, Caribbean and Pacific-European Union Joint Assembly (ACP-EU JPA).

During his first term in the Senate (2013-2022) and part of his second as Senator for Bungoma County, Hon. Wetang’ula served as the Senate Minority Leader and a member of the Senate Business Committee. He also served as a member of the Senate Standing Committee on Defence & Foreign Relations and the Committee on Finance & Budget. Prior to 2013, Dr. Wetang’ula held various Cabinet portfolios, between 2011 and 2013; Minister for Trade, Chairperson of the African Union Peace & Security Council. Further, between 2004 and 2007, he served as an Assistant Minister for Foreign Affairs before being appointed as the Minister for Foreign Affairs, a position he held up to 2011. Speaker Wetang’ula is also the Forum for the Restoration of Democracy (FORD-Kenya) party leader since 2012 upto date.

Globally, Hon. Wetang’ula seeks to continue building and strengthening parliamentary diplomacy and the long and rich relationship the Parliament of Kenya has had with key players, including the Commonwealth Parliamentary Association (CPA); the Pan-African Parliament (PAP); the Inter-Parliamentary Union (IPU); the East African Legislative Assembly (EALA) and the Organisation of African, Caribbean and Pacific States (OACPS).